GPR133 CHO
CBP71668
询 价
索取protocol
产品描述
产品数据库
| I. Background | |
|
GPR133（ADGRD1）是一种粘附类G蛋白偶联受体，顺利获得Gαs/cAMP通路传递信号。它在胶质母细胞瘤（GBM）的缺氧区域高表达，是肿瘤生长所必需的，抑制其表达可显著减少肿瘤形成并延长生存期。此外，GPR133还参与骨代谢调控，其激活可抑制破骨细胞生成、防止骨质流失，并促进骨形成。 |
|
| II. Description | |
|
GPR133 CHO 细胞，在 CHO-K1 细胞的基础上，稳定表达GPR133。 |
|
| III. Introduction | |
| Expressed gene: | GPR133 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K + 10%FBS + 5μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Transducer: | Gs |
IV. Representative Data Figure 1. HTRF cAMP Assay with GPR133 CHO(C74). |
|
