IGSF8 HEK293
CBP74651
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| I. Background | |
| IGSF8(免疫球蛋白超家族成员8)是一种单次跨膜糖蛋白,属于EWI亚家族,顺利获得与CD9、CD81等四跨膜蛋白直接结合,参与调控细胞迁移、增殖及神经元网络维持。近年来,它被鉴定为一种先天免疫检查点,在肿瘤免疫逃逸中发挥关键作用,单独阻断IGSF8或与抗PD-1联用均可抑制肿瘤生长。此外,IGSF8还参与维持髓系白血病干细胞的干性,其高表达与多种癌症的不良预后相关。 | |
| II. Description | |
| IGSF8 HEK293细胞,在 HEK293细胞的基础上,稳定表达 IGSF8 。 | |
| III. Introduction | |
| Expressed gene: | IGSF8 |
| Host Cell: | HEK293 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
Figure 1. Recombinant IGSF8 HEK293 constitutively expressing IGSF8. |
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